[HTML][HTML] The role of nitric oxide on male and female reproduction

S Dutta, P Sengupta - The Malaysian journal of medical sciences …, 2022 - ncbi.nlm.nih.gov
Nitric oxide (NO), a reactive nitrogen species, is a molecule of high physiological as well as
pathological importance. Physiological mechanisms mediated by NO mainly include …

Calcium in red blood cells—a perilous balance

A Bogdanova, A Makhro, J Wang, P Lipp… - International journal of …, 2013 - mdpi.com
Ca2+ is a universal signalling molecule involved in regulating cell cycle and fate,
metabolism and structural integrity, motility and volume. Like other cells, red blood cells …

Mechanism of nitric oxide synthase regulation: electron transfer and interdomain interactions

C Feng - Coordination chemistry reviews, 2012 - Elsevier
Mammalian nitric oxide synthase (NOS), a flavo-hemoprotein, tightly regulates nitric oxide
(NO) synthesis and thereby its dual biological activities as a key signaling molecule for …

Arabidopsis CaM1 and CaM4 Promote Nitric Oxide Production and Salt Resistance by Inhibiting S-Nitrosoglutathione Reductase via Direct Binding

S Zhou, L Jia, H Chu, D Wu, X Peng, X Liu… - PLoS …, 2016 - journals.plos.org
Salt is a major threat to plant growth and crop productivity. Calmodulin (CaM), the most
important multifunctional Ca2+ sensor protein in plants, mediates reactions against …

Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain

DJ Stuehr, J Tejero, MM Haque - The FEBS journal, 2009 - Wiley Online Library
Nitric oxide synthases belong to a family of dual‐flavin enzymes that transfer electrons from
NAD (P) H to a variety of heme protein acceptors. During catalysis, their FMN subdomain …

Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase

C Xia, I Misra, T Iyanagi, JJP Kim - Journal of Biological Chemistry, 2009 - ASBMB
Nitric-oxide synthases (NOSs) catalyze the conversion of l-arginine to nitric oxide and
citrulline. There are three NOS isozymes, each with a different physiological role: neuronal …

Structural consequences of calmodulin EF hand mutations

M Piazza, V Taiakina, T Dieckmann… - Biochemistry, 2017 - ACS Publications
Calmodulin (CaM) is a cytosolic Ca2+-binding protein that serves as a control element for
many enzymes. It consists of two globular domains, each containing two EF hand pairs …

Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation

M Piazza, K Futrega, DE Spratt, T Dieckmann… - Biochemistry, 2012 - ACS Publications
Nitric oxide synthase (NOS) plays a major role in a number of key physiological and
pathological processes. Knowledge of how this is regulated is important. The small acidic …

Role of the N- and C-Lobes of Calmodulin in the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II

A Forest, MT Swulius, JKY Tse, JM Bradshaw… - Biochemistry, 2008 - ACS Publications
Understanding the principles of calmodulin (CaM) activation of target enzymes will help
delineate how this seemingly simple molecule can play such a complex role in transducing …

Dynamics of nitric oxide synthase–calmodulin interactions at physiological calcium concentrations

M Piazza, JG Guillemette, T Dieckmann - Biochemistry, 2015 - ACS Publications
The intracellular Ca2+ concentration is an important regulator of many cellular functions.
The small acidic protein calmodulin (CaM) serves as a Ca2+ sensor and control element for …