Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities

M Silberstein, N Nesbit, J Cai, PH Lee - Journal of genetics and genomics, 2021 - Elsevier
Pathway analysis, also known as gene-set enrichment analysis, is a multilocus analytic
strategy that integrates a priori, biological knowledge into the statistical analysis of high …

Olfactory coding from the periphery to higher brain centers in the Drosophila brain

Y Seki, HKM Dweck, J Rybak, D Wicher, S Sachse… - BMC biology, 2017 - Springer
Background Odor information is processed through multiple receptor-glomerular channels in
the first order olfactory center, the antennal lobe (AL), then reformatted into higher brain …

Dose-related effects of inhaled essential oils on behavioural measures of anxiety and depression and biomarkers of oxidative stress

M Aponso, A Patti, LE Bennett - Journal of ethnopharmacology, 2020 - Elsevier
Abstract Ethnopharmacological relevance Essential oils (EOs) are extracts of organic,
volatile metabolites of plants that are typically oily liquids at ambient temperatures …

iORbase: A database for the prediction of the structures and functions of insect olfactory receptors

Q Li, YF Zhang, TM Zhang, JH Wan, YD Zhang… - Insect …, 2023 - Wiley Online Library
Insect olfactory receptors (iORs) with atypical 7‐transmembrane domains, unlike Chordata
olfactory receptors, are not in the GPCR protein family. iORs selectively bind to volatile …

InsectOR—Webserver for sensitive identification of insect olfactory receptor genes from non-model genomes

SD Karpe, V Tiwari, S Ramanathan - PLoS One, 2021 - journals.plos.org
Insect Olfactory Receptors (ORs) are diverse family of membrane protein receptors
responsible for most of the insect olfactory perception and communication, and hence they …

Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa …

SD Karpe, S Dhingra, A Brockmann, R Sowdhamini - Scientific Reports, 2017 - nature.com
Olfactory/odorant receptors (ORs) probably govern eusocial behaviour in honey bees
through detection of cuticular hydrocarbons (CHCs) and queen mandibular gland …

Topology prediction of insect olfactory receptors

V Tiwari, SD Karpe, R Sowdhamini - Current Opinion in Structural Biology, 2019 - Elsevier
Highlights•Insect Olfactory Receptors retain a different topology than GPCRs and vertebrate
ORs.•Multiple TMH prediction methods exist and few of them are robust and suitable for …

Computational approaches for decoding select odorant-olfactory receptor interactions using mini-virtual screening

K Harini, R Sowdhamini - PloS one, 2015 - journals.plos.org
Olfactory receptors (ORs) belong to the class A G-Protein Coupled Receptor superfamily of
proteins. Unlike G-Protein Coupled Receptors, ORs exhibit a combinatorial response to …

A functional agonist of insect olfactory receptors: Behavior, physiology and structure

S Batra, J Corcoran, DD Zhang, P Pal, U KP… - Frontiers in Cellular …, 2019 - frontiersin.org
Chemical signaling is ubiquitous and employs a variety of receptor types to detect the
cacophony of molecules relevant for each living organism. Insects, our most diverse taxon …

Molecular determinants of the olfactory receptor Olfr544 activation by azelaic acid

TT Thach, YJ Hong, S Lee, SJ Lee - Biochemical and biophysical research …, 2017 - Elsevier
The mouse olfactory receptor Olfr544 is expressed in several non-olfactory tissues and has
been suggested as a functional receptor regulating different signaling pathways. However …