Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …

Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and
bone tumors, pose significant health challenges due to their debilitating effects on the …

Osteoarthritis (OA) is a highly prevalent and disabling joint disease, characterized by
pathological progressive joint deformation and clinical symptoms of pain. Disease-modifying …

Osteoarthritis (OA) is a chronic condition characterized by degeneration of the articular
cartilage and subsequent bone hyperplasia. With the increasing prevalence driven by …

Cartilage regeneration relies on adequate and continuous bioenergy supply to facilitate
cellular differentiation and extracellular matrix synthesis. Chondrocytes frequently undergo …

Osteoarthritis (OA) is an age-related or post-traumatic degenerative whole joint disease
characterized by the rupture of articular cartilage homeostasis, the regulatory mechanisms of …

While our understanding of pain is rapidly growing, some areas of pain research are lagging
behind. This article discusses two current and inter-related gaps in knowledge that are in …

Osteoarthritis (OA) is an age-related cartilage-degenerating joint disease. Mitochondrial
dysfunction has been reported to promote the development of OA. Poly (ADP-ribose) …

Introduction Osteoarthritis (OA) related pain has affected millions of people worldwide.
However, the current pharmacological options for managing OA-related pain have not …

Voltage-gated sodium channels (VGSCs) are best known for their role in the generation and
propagation of action potentials in neurons, muscle cells, and cardiac myocytes, which have …