Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

K Kisler, AR Nelson, A Montagne… - Nature Reviews …, 2017 - nature.com
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …

Neurovascular coupling: motive unknown

PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Coupling mechanism and significance of the BOLD signal: a status report

EMC Hillman - Annual review of neuroscience, 2014 - annualreviews.org
Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

Astrocyte regulation of blood flow in the brain

BA MacVicar, EA Newman - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Neuronal activity results in increased blood flow in the brain, a response named functional
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …

Biological detection by optical oxygen sensing

DB Papkovsky, RI Dmitriev - Chemical Society Reviews, 2013 - pubs.rsc.org
Recent developments in the area of biological detection by optical sensing of molecular
oxygen (O2) are reviewed, with particular emphasis on the quenched-phosphorescence O2 …

Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain

AY Shih, JD Driscoll, PJ Drew… - Journal of Cerebral …, 2012 - journals.sagepub.com
The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

IG Gould, P Tsai, D Kleinfeld… - Journal of Cerebral …, 2017 - journals.sagepub.com
The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …

The physics of functional magnetic resonance imaging (fMRI)

RB Buxton - Reports on Progress in Physics, 2013 - iopscience.iop.org
Functional magnetic resonance imaging (fMRI) is a methodology for detecting dynamic
patterns of activity in the working human brain. Although the initial discoveries that led to …

Brain microvasculature has a common topology with local differences in geometry that match metabolic load

X Ji, T Ferreira, B Friedman, R Liu, H Liechty, E Bas… - Neuron, 2021 - cell.com
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …