Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

A role of coagulation proteases in kidney disease beyond their function in normal
haemostasis and thrombosis has long been suspected, and studies performed in the past 15 …

Podocyte dysfunction is a detrimental feature in diabetic nephropathy, with loss of nephrin
integrity contributing to diabetic podocytopathy. MicroRNAs (miRs) reportedly modulate the …

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its
pathophysiological relevance and the mechanisms that compromise adaptive ER signalling …

Glucose-induced reactive oxygen species (ROS) production initiates podocyte apoptosis,
which represents a novel early mechanism leading to diabetic nephropathy (DN). Here, we …

Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the
pathophysiologic relevance of this process remains obscure. Here, we administered two …

Background: Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical
role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that …

The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the
receptors and signaling mechanism through which aPC conveys cytoprotection in various …

Background—Recent findings suggest that chronic kidney disease (CKD) may be
associated with an increased risk of venous thromboembolism (VTE). Given the high …

Objective—The role of hypercoagulability in the pathogenesis of diabetic nephropathy (DN)
remains elusive. We recently reported the increased infiltration of macrophages expressing …