Cell fate is shaped by a unique gene expression program, which reflects the concerted
action of multilayered precise regulation. Substantial research attention has been paid to the …

Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of
fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to …

Background CircRNA is recognized for its significant regulatory function across various
cancers. However, its regulatory role in non-small cell lung cancer (NSCLC) is still largely …

Signaling pathways drive cell fate transitions largely by changing gene expression.
However, the mechanisms for rapid and selective transcriptome rewiring in response to …

How RNA-binding proteins (RBPs) convey regulatory instructions to the core effectors of
RNA processing is unclear. Here, we document the existence and functions of a multivalent …

Metastasis is the leading cause for the high mortality of lung cancer, however, effective anti‐
metastatic drugs are still limited. Here it is reported that the RNA‐binding protein RBMS1 is …

Immunosuppression characterizes the tumour microenvironment in HCC, and recent studies
have implicated RNA-binding proteins (RBPs) in the development of HCC. Here, we …

Phosphorylation is a major post-translation modification (PTM) of proteins which is finely
tuned by the activity of several hundred kinases and phosphatases. It controls most if not all …

The intricate interplay between RNA molecules and small ligands plays a pivotal role in
regulating biological processes, underscoring the necessity for accurate prediction models …

Abstract NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex,
critical for post-transcriptional regulation in eukaryotes, but how this module contributes to …