The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Flow biocatalysis: A challenging alternative for the synthesis of APIs and natural compounds

M Santi, L Sancineto, V Nascimento… - International journal of …, 2021 - mdpi.com
Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts
in both industry and academia. In the last two decades, the interest in biocatalytic …

Recent advances in artificial enzyme cascades for the production of value-added chemicals

Z Wang, BS Sekar, Z Li - Bioresource Technology, 2021 - Elsevier
Enzyme cascades are efficient tools to perform multi-step synthesis in one-pot in a green
and sustainable manner, enabling non-natural synthesis of valuable chemicals from easily …

Magnetic micro-macro biocatalysts applied to industrial bioprocesses

J Del Arco, AR Alcántara, R Fernández-Lafuente… - Bioresource …, 2021 - Elsevier
The use of magnetic biocatalysts is highly beneficial in bioprocesses technology, as it allows
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …

Biocatalyzed synthesis of glycostructures with anti-infective activity

P Hoyos, A Perona, T Bavaro, F Berini… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Molecules containing carbohydrate moieties play essential roles in fighting a
variety of bacterial and viral infections. Consequently, the design of new carbohydrate …

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues

SC Cosgrove, GJ Miller - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …

Snapshots of the reaction coordinate of a thermophilic 2′-deoxyribonucleoside/ribonucleoside transferase

P Tang, CJ Harding, AL Dickson, RG da Silva… - ACS …, 2024 - ACS Publications
Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other
molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of …

Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives

S Westarp, F Kaspar, P Neubauer, A Kurreck - Current Opinion in …, 2022 - Elsevier
Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable
synthetic tool. However, despite the recent advances in nucleoside phosphorylase …

Sustainable flow‐synthesis of (bulky) nucleoside drugs by a novel and highly stable nucleoside phosphorylase immobilized on reusable supports

AI Benítez‐Mateos, F Paradisi - ChemSusChem, 2022 - Wiley Online Library
The continuous synthesis of valuable nucleoside drugs was achieved in up to 99%
conversion by using a novel halotolerant purine nucleoside phosphorylase from Halomonas …

Immobilization and stabilization of an engineered acyltransferase for the continuous biosynthesis of simvastatin in packed-bed reactors

G García-Marquina, J Langer… - ACS Sustainable …, 2022 - ACS Publications
Simvastatin is a top-selling cholesterol-lowering drug traditionally obtained through a semi-
synthetic process starting from lovastatin. However, this process is cost-demanding and …