Cells must replicate and segregate their DNA to daughter cells accurately to maintain
genome stability and prevent cancer. DNA replication is usually fast and accurate, with …

DNA helicases, known for their fundamentally important roles in genomic stability, are high
profile players in cancer. Not only are there monogenic helicase disorders with a strong …

In Saccharomyces cerevisiae, the Pif1 helicase functions in both nuclear and mitochondrial
DNA replication and repair processes, preferentially unwinding RNA: DNA hybrids and …

The conserved nuclease-helicase DNA2 has been linked to mitochondrial myopathy, Seckel
syndrome, and cancer. Across species, the protein is indispensable for cell proliferation. On …

Yen1 and GEN1 are members of the Rad2/XPG family of nucleases that were identified as
the first canonical nuclear Holliday junction (HJ) resolvases in budding yeast and humans …

FANCD2 protein, a key coordinator and effector of the interstrand crosslink repair pathway,
is also required to prevent excessive nascent strand degradation at hydroxyurea-induced …

The disease-associated nuclease–helicase DNA2 has been implicated in DNA end-
resection during DNA double-strand break repair, Okazaki fragment processing, and the …

Mammalian DNA replication relies on various DNA helicase and nuclease activities to
ensure accurate genetic duplication, but how different helicase and nuclease activities are …

PIF1 family helicases are evolutionarily conserved among prokaryotes and eukaryotes.
These enzymes function to support genome integrity by participating in multiple DNA …

Iron–sulfur (Fe-S) clusters are essential cofactors found in many proteins in the
mitochondria, cytosol, and nucleus of the cell. These versatile cofactors may undergo …