Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Significance: Autophagy is a highly conserved eukaryotic cellular recycling process.
Through the degradation of cytoplasmic organelles, proteins, and macromolecules, and the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …