Fluorescence microscopy is one of the most powerful tools for elucidating the cellular
functions of proteins and other molecules. In many cases, the function of a molecule can be …

It is generally accepted that the functional compartmentalization of eukaryotic cells is
reflected by the differential occurrence of proteins in their compartments. The location and …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Traditionally viewed as an autodigestive pathway, autophagy also facilitates cellular
secretion; however, the mechanisms underlying these processes remain unclear. Here, we …

Liquid–liquid phase separation is a major mechanism of subcellular compartmentalization,.
Although the segregation of RNA into phase-separated condensates broadly affects RNA …

The intracellular environment hosts a large number of cancer-and other disease-relevant
human proteins. Targeting these with internalized antibodies would allow therapeutic …

The major energy source for most cells is glucose, from which ATP is generated via
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …

The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …

Insight into the function and regulation of biological molecules can often be obtained by
determining which cell structures and other molecules they localize with (ie. colocalization) …

Stress granules (SG) are membrane‐less compartments involved in regulating mRNAs
during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as …