α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

S Bhattarai, M Freundlieb, J Pippel… - Journal of medicinal …, 2015 - ACS Publications
ecto-5′-Nucleotidase (e N, CD73) catalyzes the hydrolysis of extracellular AMP to
adenosine. e N inhibitors have potential for use as cancer therapeutics. The e N inhibitor α …

Carbohydrate derivatives fight against malaria parasite as anti-plasmodial agents

K Singh, RP Tripathi - Carbohydrate Research, 2023 - Elsevier
Malaria, a prevalent fatal disease around the world is caused by Plasmodium sp. and is
transmitted by the bite of female Anopheles mosquito. It is leading cause of death in this …

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

K Doležal, I Popa, E Hauserová, L Spíchal… - Bioorganic & medicinal …, 2007 - Elsevier
Cytokinin activity of forty-eight 6-benzyladenosine derivatives at both the receptor and
cellular levels as well as their anticancer properties were compared in various in vitro …

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ-and δ-lactams via a ' …

CC Musonda, J Gut, PJ Rosenthal, V Yardley… - Bioorganic & medicinal …, 2006 - Elsevier
A parallel synthesis of a new series of 4-aminoquinoline γ-and δ-lactams synthesized via the
Ugi 3-component 4-centre multicomponent reaction is described. The basicity of the …

Neuroprotective Principles from Gastrodia elata

NK Huang, Y Chern, JM Fang, CI Lin… - Journal of natural …, 2007 - ACS Publications
Serum deprivation-induced neuronal-like PC12 cell apoptosis was used as an
ischemic/hypoxic model to screen neuroprotective compounds from the rhizomes of …

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

CC Musonda, D Taylor, J Lehman, J Gut… - Bioorganic & medicinal …, 2004 - Elsevier
The synthesis of a new class of Ugi adducts incorporating the 4-aminoquinoline moiety is
described. The novel compounds are active against both chloroquine-sensitive and …

Nano-SiO2: a green, efficient, and reusable heterogeneous catalyst for the synthesis of quinazolinone derivatives

MR Mousavi, MT Maghsoodlou - Journal of the Iranian Chemical Society, 2015 - Springer
A highly efficient and general method is applied for the multicomponent synthesis of
quinazolinone derivatives from cyclocondensation of aromatic aldehydes and dimedone …

The discovery of novel antimicrobial agents through the application of isocyanide-based multicomponent reactions

S Quazi, MT Rashid, JA Malik, S Gavas - Antibiotics, 2023 - mdpi.com
Multicomponent reactions (MCR) have been used to synthesize a wide range of analogs
from several classes of heterocyclic compounds, with multifaceted medicinal uses. The …

A simple and convenient synthesis of [1,2,4]triazolo/benzimidazolo ‎quinazolinone and [1,2,4]triazolo[1,5-a]pyrimidine derivatives catalyzed by ‎DABCO-based ionic …

N Seyyedi, F Shirini, MSN ‎ Langarudi… - Journal of the Iranian …, 2017 - Springer
DABCO-based ionic liquids were utilized for the preparation of [1, 2, 4]
triazolo/benzimidazolo quinazolinone and [1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives in …

2,N6-Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities

B Rodenko, AM van der Burg, MJ Wanner… - Antimicrobial agents …, 2007 - Am Soc Microbiol
ABSTRACT A library of 2, N6-disubstituted adenosine analogs was synthesized and the
analogs were tested for their antiprotozoal activities. It was found that 2-methoxy and 2 …