Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the
first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma …

Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest malignancies,
with dismal survival rates and extremely prevalent chemoresistance. Gemcitabine is one of …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Pancreatic ductal adenocarcinoma (PDAC) is on of the most lethal malignant tumors with
relatively poor prognosis, characterized with insufficient drug penetration, low immune …

Ultrasound imaging presents many positive attributes, including safety, real-time imaging,
universal accessibility, and cost. However, inherent difficulties in discrimination between soft …

Objective Pancreatic cancer is one of the most lethal human malignancies. Gemcitabine is
widely used to treat pancreatic cancer, and the resistance to chemotherapy is the major …

Harsh environments in poorly perfused tumor regions may select for traits driving cancer
aggressiveness. Here, we investigated whether tumor acidosis interacts with driver …

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent
therapeutic agents since their introduction in 1950, deployed widely in the treatment of …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC, also known as pancreatic
cancer) is one of the deadliest tumor types, characterized by poor prognosis, profound …

The APOBEC3 (APOBEC3A-H) enzyme family as a part of the human innate immune system
deaminates cytosine to uracil in single-stranded DNA (ssDNA) and thereby prevents the …