As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β (Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores
of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) …