OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Understanding the biology underlying the mechanisms and pathways regulating pancreatic
β cell development is necessary to understand the pathology of diabetes mellitus (DM) …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …

Of paramount importance for the development of cell therapies to treat diabetes is the
production of sufficient numbers of pancreatic endocrine cells that function similarly to …

Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell
failure in diabetes. However, the molecular mechanisms that underlie the loss of beta cell …

The reversible nature of early type 2 diabetes has been demonstrated in in vivo human
studies. Recent in vivo and in vitro studies of β-cell biology have established that the β-cell …

MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles
in differentiated β‐cells remain unclear. Here, we show that miRNA inactivation in β‐cells of …

To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be
recapitulated in the mouse, we compared C57BL/6J mice fed a Western‐style diet (WD) to …

Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates
during fetal development. The pancreas develops through simple budlike structures on the …