Light has received increased attention for various chemical reactions but also in
combination with biocatalytic reactions. Because currently only a few enzymatic reactions …

Sulphonamide motifs are widely found in many drug candidates with relevant biological
activity. Moreover, sulphonamide azo dyes are interesting candidates for synthetic chemists …

Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

Despite the power of photopharmacology for interrogating signaling proteins, many
photopharmacological systems are limited by their efficiency, speed, or spectral properties …

Two azobenzenesulfonamide molecules with thermally stable cis configurations resulting
from fluorination of positions ortho to the azo group are reported that can differentially …

Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …

Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …

The racemase enzymes convert l‐amino acids to their d‐isomer. The reaction proceeds
through a stepwise deprotonation–reprotonation mechanism that is assisted by a pyridoxal …

Peptide fibrillization is crucial in biological processes such as amyloid-related diseases and
hormone storage, involving complex transitions between folded, unfolded, and aggregated …

Light-dependent or light-stimulated catalysis provides a multitude of perspectives for
implementation in technological or biomedical applications. Despite substantial progress …