[HTML][HTML] Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications

M Guo, X Sun, J Chen, T Cai - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Global analysis of the mechanical properties of organic crystals

DP Karothu, J Mahmoud Halabi… - Angewandte Chemie …, 2022 - Wiley Online Library
Organic crystals, although widely studied, have not been considered nascent candidate
materials in engineering design. Here we summarize the mechanical properties of organic …

The rise of the dynamic crystals

P Naumov, DP Karothu, E Ahmed… - Journal of the …, 2020 - ACS Publications
The anticipated shift in the focal point of interest of solid-state chemists, crystal engineers,
and crystallographers from structure to properties to function parallels the need to apply our …

Elastic molecular crystals: From serendipity to design to applications

S Ghosh, MK Mishra - Crystal Growth & Design, 2021 - ACS Publications
The mechanical adaptiveness of long-range ordered molecular crystals has long been
ignored due to their brittle nature, unlike polymers and flexible biomaterials. However, the …

Exceptionally elastic single-component pharmaceutical crystals

K Wang, MK Mishra, CC Sun - Chemistry of Materials, 2019 - ACS Publications
We report here the first elastically bendable single-component pharmaceutical crystal,
celecoxib. Interlocked molecular packing without the slip plane and the presence of an …

Remarkably distinct mechanical flexibility in three structurally similar semiconducting organic crystals studied by nanoindentation and molecular dynamics

R Devarapalli, SB Kadambi, CT Chen… - Chemistry of …, 2019 - ACS Publications
Distinct macroscopic mechanical responses of the three crystals of naphthalene diimide
derivatives, 1Me, 1Et, and 1nPr, studied here are very intriguing because their molecular …

Crystalline multicomponent solids: An alternative for addressing the hygroscopicity issue in pharmaceutical materials

TS Thakur, R Thakuria - Crystal Growth & Design, 2020 - ACS Publications
The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

Research progress of mechanically flexible molecular crystals: From bending mechanisms to applications

Z Zhuo, J Lin, J Li, S Wu, W Hu, J Gong - Chemical Engineering Journal, 2022 - Elsevier
The emerging of flexible molecular crystals is considered as one of the most exciting
developments in the organic solid chemistry research as it brings the light for the application …

Intermolecular interactions in functional crystalline materials: from data to knowledge

AV Vologzhanina - Crystals, 2019 - mdpi.com
Intermolecular interactions of organic, inorganic, and organometallic compounds are the key
to many composition–structure and structure–property networks. In this review, some of …

Nanoindentation of molecular crystals: Lessons learned from aspirin

BPA Gabriele, CJ Williams, ME Lauer… - Crystal Growth & …, 2020 - ACS Publications
Nanoindentation enables the measurement of mechanical properties from single crystals
with dimensions of a few micrometers. This experimental technique, however, has only …