MeHg is an environmental neurotoxin that can adversely affect the development of the
nervous system. The molecular integrity of chromatin in the nucleus is an important target of …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Microprocessor (MP) is a complex involved in initiating the biogenesis of microRNAs
(miRNAs) by cleaving primary microRNAs (pri-miRNAs). miRNAs are small single-stranded …

MicroRNAs (miRNAs) were first discovered in C. elegans as essential post-transcriptional
regulators of gene expression. Since their initial discovery, miRNAs have been implicated in …

MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that direct
mRNA repression. miRNAs are also the subject of regulation. For example, some miRNAs …

RNA passed from parents to progeny controls several aspects of early development. The
germline of the free-living nematode Caenorhabditis elegans contains many families of …

Abstract microRNAs are frequently modified by addition of untemplated nucleotides to the
3′ end, but the role of this tailing is often unclear. Here we characterize the prevalence and …

Elucidating the expression of microRNAs in developing single cells is critical for functional
discovery. Here, we construct scCAMERA (single-cell cartography of microRNA expression …

ABSTRACT The Jacques Monod Conference on 'Growth and regeneration during
development and aging'was organized by Claude Desplan and Allison Bardin in May 2023 …

Many microRNAs (miRNAs) are expressed with high spatiotemporal specificity during
organismal development, with some being limited to rare cell types, often embedded in …