10 Years of belimumab experience: What have we learnt?

RA Levy, T Gonzalez-Rivera, M Khamashta, NL Fox… - Lupus, 2021 - journals.sagepub.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease
affecting both adults and children. Belimumab is the only biologic approved for SLE, and the …

Impact of glucocorticoids on the incidence of lupus-related major organ damage: a systematic literature review and meta-regression analysis of longitudinal …

MF Ugarte-Gil, A Mak, J Leong… - Lupus science & …, 2021 - lupus.bmj.com
Objective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC)
exposure are known to contribute to irreversible organ damage. We aimed to examine the …

Anifrolumab reduces flare rates in patients with moderate to severe systemic lupus erythematosus

R Furie, EF Morand, AD Askanase, EM Vital… - Lupus, 2021 - journals.sagepub.com
Background Systemic lupus erythematosus (SLE) management objectives include
preventing disease flares while minimizing glucocorticoid exposure. Pooled data from the …

Conceptual framework for defining disease modification in systemic lupus erythematosus: a call for formal criteria

R van Vollenhoven, AD Askanase… - Lupus science & …, 2022 - lupus.bmj.com
Disease modification has become a well-established concept in several therapeutic areas;
however, no widely accepted definition of disease modification exists for SLE. We reviewed …

[HTML][HTML] Reframing health disparities in SLE: A critical reassessment of racial and ethnic differences in lupus disease outcomes

I Parodis, C Lanata, D Nikolopoulos, A Blazer… - Best Practice & …, 2023 - Elsevier
Health disparities in the prevalence and outcomes of systemic lupus erythematosus (SLE)
are well documented across racial and ethnic groups. Similar to other chronic diseases …

Is it safe to withdraw low-dose glucocorticoids in SLE patients in remission?

A Mathian, L Arnaud, G Ruiz-Irastorza - Autoimmunity Reviews, 2024 - Elsevier
Glucocorticoids (GCs) remain a cornerstone of the treatment of Systemic Lupus
Erythematosus (SLE). Numerous studies have emphasized the risk of damage accrual in …

Pathological mechanisms of abnormal iron metabolism and mitochondrial dysfunction in systemic lupus erythematosus

C Wincup, N Sawford, A Rahman - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Systemic lupus erythematosus [SLE] is a chronic, autoimmune condition
characterized by the formation of autoantibodies directed against nuclear components and …

Impact of belimumab on organ damage in systemic lupus erythematosus

MB Urowitz, C Aranow, Y Asukai… - Arthritis Care & …, 2022 - Wiley Online Library
Organ damage is a key determinant of poor long‐term prognosis and early death in patients
with systemic lupus erythematosus (SLE). Prevention of damage is a key treatment goal of …

[HTML][HTML] From incomplete to complete systemic lupus erythematosus; A review of the predictive serological immune markers

WM Lambers, J Westra, H Bootsma… - Seminars in Arthritis and …, 2021 - Elsevier
Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease.
A main challenge faced by clinicians is early identification of SLE, frequently resulting in …

Indirect treatment comparison of anifrolumab efficacy versus belimumab in adults with systemic lupus erythematosus

IN Bruce, S Golam, J Steenkamp… - Journal of …, 2022 - becarispublishing.com
Aim: Assess the comparative efficacy of anifrolumab 300 mg versus belimumab 10 mg/kg in
adults with moderate-to-severe systemic lupus erythematosus (SLE) receiving standard …