In recent decades many advances have occurred in the understanding of the role of
cytokines in breast cancer. New signalling pathways of interleukin (IL)-1 family, IL-6, IL-11, IL …

This article reports on recent advances on metastatic breast cancer. Detection, prognostic
factors, predictors of response to therapy and therapy, with particular regard to targeted …

Purpose: We reported previously that≥ 5 circulating tumor cells (CTC) in 7.5 mL blood at
baseline and at first follow-up in 177 patients with metastatic breast cancer (MBC) were …

Background: We aimed to determine the prognostic impact of time between primary breast
cancer and diagnosis of distant metastasis (metastatic-free interval, MFI) on the survival of …

Background: Treatment of metastatic breast cancer (MBC) remains palliative. Patients with
MBC represent a heterogeneous group whose prognosis and outcome may be dependent …

Contrary to the situation in early breast cancer, little is known about the prognostic relevance
of the hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) in …

Prediction of survival for patients with metastatic breast cancer is often inaccurate and may
be helped by new biological parameters. Tumour growth being angiogenesis-dependent, it …

Liver function tests (LFTs) have been reported as independent predictors of non-liver
disease-related morbidity and mortality in general population and cancer patients. In this …

Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide
range of cancer cells and plays important roles in cancer progression and metastasis …

Purpose: Poxviral vectors have a proven safety record and can be used to incorporate
multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic …