The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis
necessitate therapeutic improvement. Current advances in AML research yield important …

Heat-shock proteins are upregulated in cancer and protect several client proteins from
degradation. Therefore, they contribute to tumorigenesis and cancer metastasis by reducing …

The heat shock response (HSR) is a highly conserved cellular pathway that is responsible
for stress relief and the refolding of denatured proteins [1]. When a host cell is exposed to …

Simple Summary AML is a highly heterogeneous hematological disease and is the second
most common form of leukemia. Around 40% of AML patients display elevated nuclear NF …

Introduction: Alzheimer's disease, characterized by the accumulation of
hyperphosphorylated tau and β amyloid (Aβ), currently lacks effective treatment. Chaperone …

Hsp90 is a molecular chaperone that maintains the structural and functional integrity of
various client proteins involved in signaling and many other functions of cancer cells. The …

Dasatinib and radotinib are oral BCR-ABL tyrosine kinase inhibitors that were developed as
drugs for the treatment of chronic myeloid leukemia. We report here that the c-KIT (CD117) …

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells.
Since KIT is activated by overexpression or mutation and plays an important role in the …

Background Acute myeloid leukemia (AML) is the most common malignancy of the
hematological system, and there are currently a number of studies regarding abnormal …

This study investigated the expression of heat shock protein 90 alpha (Hsp90α) in acute
leukemia cells. The expression of Hsp90α was investigated in leukemia cell lines and …