Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …

Asymmetric catalysis is a major theme of research in contemporary synthetic organic
chemistry. The discovery of general strategies for highly enantioselective photochemical …

Developing synthetically useful enzymatic reactions that are not known in biochemistry and
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …

Naturally evolved enzymes, despite their astonishingly large variety and functional diversity,
operate predominantly through thermochemical activation. Integrating prominent …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Conspectus Harnessing biocatalysts for novel abiological transformations is a longstanding
goal of synthetic chemistry. Combining the merits of biocatalysis and photocatalysis allows …

Since the discovery of Hofmann–Löffler–Freytag reaction more than 130 years ago, both the
structure and reactivity of nitrogen-centred radicals have been widely studied. Nevertheless …

The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …