Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …

The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a
major focus of COVID-19 research due to its clinical relevance and importance in vaccine …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …

Objective The presence of anti-citrullinated protein antibodies (ACPA) and IgM-rheumatoid
factor (IgM-RF) years before the clinical diagnosis of rheumatoid arthritis (RA) suggests they …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, and affects 0.5–
1% of the population. Although it poses a considerable health problem, relatively little …

Genetically modified immune responses to infections and self-antigens initiate most forms of
GN by generating pathogen-and danger-associated molecular patterns that stimulate Toll …

Monoclonal antibody (mAb) therapy has successfully been introduced as treatment of
several lymphomas and leukemias. However, solid tumors reduce the efficacy of mAb …