Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects
J Ru, Y Wang, Z Li, J Wang, C Ren, J Zhang - European Journal of …, 2023 - Elsevier
Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Identification of anti-fibrotic and pro-apoptotic bioactive compounds from Ganoderma formosanum and their possible mechanisms in modulating TGF-β1-induced lung …
Abstract Ethnopharmacological relevance The Compendium of Materia Medica and the
Classic of Materia Medica, the two most prominent records of traditional Chinese medicine …
Classic of Materia Medica, the two most prominent records of traditional Chinese medicine …
Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase
X Yang, G Lin, Y Chen, X Lei, Y Ou, Y Yan… - ACS Central …, 2024 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited
treatment options. Thus, it is essential to investigate potential druggable targets to improve …
treatment options. Thus, it is essential to investigate potential druggable targets to improve …
siTGF-β1 and pirfenidone contained Ionizable-Liposomal nanodrug for enhanced treatment of Idiopathic pulmonary fibrosis
C Yu, Q Xu, X Cao, S Cheng, Z Zhang… - Chemical Engineering …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a challenging interstitial lung disease characterized by
heterogeneous manifestations and significant mortality. Due to the relative complexity of IPF …
heterogeneous manifestations and significant mortality. Due to the relative complexity of IPF …
Histone deacetylases: potential therapeutic targets for idiopathic pulmonary fibrosis
H Cheng, S Jiang, J Cai, Z Luo, X Li… - Frontiers in Cell and …, 2024 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown origin and
the most common interstitial lung disease. However, therapeutic options for IPF are limited …
the most common interstitial lung disease. However, therapeutic options for IPF are limited …
Novel quinazoline sulfonamide-based scaffolds modulate methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in immunodeficient irradiated model …
A library of new quinazoline pharmacophores bearing benzenesulfonamide moiety was
designed and synthesized. Compounds 3a–n were screened for their in vitro antimicrobial …
designed and synthesized. Compounds 3a–n were screened for their in vitro antimicrobial …
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.
Y Peng, Y Guo, S Zhang, Y Chang, S Zhang… - Bioorganic …, 2024 - Elsevier
In the chemical investigation of Inula japonica, a total of 29 sesquiterpenoids (1–29) were
obtained, including pseudoguaine-, xanthane-, eudesmane-, and 1, 10-secoeudesmane …
obtained, including pseudoguaine-, xanthane-, eudesmane-, and 1, 10-secoeudesmane …
The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods
Histone deacetylases (HDACs) are crucial in gene transcription, removing acetyl groups
from histones. They also influence the deacetylation of non-histone proteins, contributing to …
from histones. They also influence the deacetylation of non-histone proteins, contributing to …
[HTML][HTML] A narrative review of the role of HDAC6 in idiopathic pulmonary fibrosis
H Yu, S Liu, S Wang, X Gu - Journal of Thoracic Disease, 2024 - ncbi.nlm.nih.gov
Methods PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI),
Wanfang, China Biomedical Literature Service System (CBMdisc) and Web of Science were …
Wanfang, China Biomedical Literature Service System (CBMdisc) and Web of Science were …