Azole Resistance in Candida glabrata

SG Whaley, PD Rogers - Current infectious disease reports, 2016 - Springer
Candida infections have increased due to the growth and expansion of susceptible patient
populations. The azole fluconazole is the most widely prescribed antifungal, but rising rates …

Mechanisms of sterol uptake and transport in yeast

N Jacquier, R Schneiter - The Journal of steroid biochemistry and …, 2012 - Elsevier
Sterols are essential lipid components of eukaryotic membranes. Here we summarize recent
advances in understanding how sterols are transported between different membranes …

[图书][B] Larone's medically important fungi: A guide to identification

TJ Walsh, RT Hayden, DH Larone - 2018 - books.google.com
The definitive guide for identifying fungi from clinical specimens Medically Important Fungi
will expand your knowledge and support your work by: Providing detailed descriptions of the …

Changes in the sterol composition of the plasma membrane affect membrane potential, salt tolerance and the activity of multidrug resistance pumps in Saccharomyces …

M Kodedová, H Sychrová - PloS one, 2015 - journals.plos.org
We investigated the impact of the deletions of genes from the final steps in the biosynthesis
of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the …

Multiple roles of ABC transporters in yeast

S Kumari, M Kumar, NA Gaur, R Prasad - Fungal Genetics and Biology, 2021 - Elsevier
The ATP binding cassette (ABC) transporters, first discovered as high-affinity nutrient
importers in bacteria, rose to prominence when their ability to confer multidrug resistance …

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to …

CM Hull, JE Parker, O Bader, M Weig… - Antimicrobial agents …, 2012 - Am Soc Microbiol
We identified a clinical isolate of Candida glabrata (CG156) exhibiting flocculent growth and
cross-resistance to fluconazole (FLC), voriconazole (VRC), and amphotericin B (AMB), with …

Candida, Cryptococcus, and Other Yeasts of Medical Importance

SA Howell, KC Hazen, ME Brandt - Manual of clinical …, 2015 - Wiley Online Library
Summary The chapter on Candida, Cryptococcus, and other yeasts of medical importance
outlines the taxonomy, epidemiology, and clinical significance of species from as many as …

Microarray and Molecular Analyses of the Azole Resistance Mechanism in Candida glabrata Oropharyngeal Isolates

HF Tsai, LR Sammons, X Zhang, SD Suffis… - Antimicrobial agents …, 2010 - Am Soc Microbiol
ABSTRACT DNA microarrays were used to analyze Candida glabrata oropharyngeal
isolates from seven hematopoietic stem cell transplant recipients whose isolates developed …

The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum

H Nakayama, K Tanabe, M Bard… - Journal of …, 2007 - academic.oup.com
Objectives The uptake of endogenous sterol from serum may allow Candida glabrata to
survive azole treatment. This study aims to determine the contribution of a sterol transporter …

Host-pathogen interactions mediated by MDR transporters in fungi: as pleiotropic as it gets!

M Cavalheiro, P Pais, M Galocha, MC Teixeira - Genes, 2018 - mdpi.com
Fungal infections caused by Candida, Aspergillus, and Cryptococcus species are an
increasing problem worldwide, associated with very high mortality rates. The successful …