Cerebral small vessel disease

J Litak, M Mazurek, B Kulesza, P Szmygin… - International journal of …, 2020 - mdpi.com
Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders
with different pathological backgrounds. The advanced vasculature net of cerebral vessels …

Mechanisms of blood–brain barrier dysfunction in traumatic brain injury

A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury

AD Griffin, LC Turtzo, GY Parikh, A Tolpygo, Z Lodato… - Brain, 2019 - academic.oup.com
Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients
following head trauma that have previously been considered a marker of axonal injury. The …

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

AC Wehn, I Khalin, M Duering, F Hellal… - Acta neuropathologica …, 2021 - Springer
Traumatic brain injury (TBI) causes acute and subacute tissue damage, but is also
associated with chronic inflammation and progressive loss of brain tissue months and years …

The involvement of iron in traumatic brain injury and neurodegenerative disease

M Daglas, PA Adlard - Frontiers in neuroscience, 2018 - frontiersin.org
Traumatic brain injury (TBI) consists of acute and long-term pathophysiological sequelae
that ultimately lead to cognitive and motor function deficits, with age being a critical risk …

Cortical thinning in military blast compared to non-blast persistent mild traumatic brain injuries

C Eierud, DE Nathan, GH Bonavia, J Ollinger… - Neuroimage …, 2019 - Elsevier
In the military, explosive blasts are a significant cause of mild traumatic brain injuries
(mTBIs). The symptoms associated with blast mTBIs causes significant economic burdens …

Location of subcortical microbleeds and recovery of consciousness after severe traumatic brain injury

M Bianciardi, S Izzy, BR Rosen, LL Wald, BL Edlow - Neurology, 2021 - AAN Enterprises
Background In patients with severe traumatic brain injury (TBI), coma is associated with
impaired subcortical arousal mechanisms. However, it is unknown which nuclei involved in …

Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury

DJ Robles, A Dharani, KA Rostowsky, NN Chaudhari… - GeroScience, 2022 - Springer
Little is known on how mild traumatic brain injury affects white matter based on age at injury,
sex, cerebral microbleeds, and time since injury. Here, we study the fractional anisotropy of …

[HTML][HTML] A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine …

MA Morrison, S Payabvash, Y Chen, S Avadiappan… - NeuroImage: Clinical, 2018 - Elsevier
Background and purpose With extensive research efforts in place to address the clinical
relevance of cerebral microbleeds (CMBs), there remains a need for fast and accurate …