Mammalian palatogenesis is a highly regulated morphogenetic process during which the
embryonic primary and secondary palatal shelves develop as outgrowths from the medial …

Site-specific recombinase systems (Cre-loxP, Flp-FRT, and φC31-att) are transforming both
forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be …

Transposable elements have been routinely used for genetic manipulation in lower
organisms, including generating transgenic animals and insertional mutagenesis. In …

Ciliary dysfunction leads to a broad range of overlapping phenotypes, collectively termed
ciliopathies. This grouping is underscored by genetic overlap, where causal genes can also …

Abstract Characterization of previously described intraflagellar transport (IFT) mouse
mutants has led to the proposition that normal primary cilia are required for mammalian cells …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a
transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano …

The Hedgehog signaling pathway is essential for many aspects of normal embryonic
development, including formation and patterning of the neural tube. Absence of the sonic …

Orofacial clefts are common birth defects of multifactorial etiology. Several novel approaches
have recently been applied to investigate the causes of clefts. These include examining …

Polycystins are a family of eight-transmembrane proteins united by sequence homology.
The name stems from the identification of mutations in genes encoding polycystin-1 and-2 in …