GABAA receptors: structure, function, pharmacology, and related disorders

A Ghit, D Assal, AS Al-Shami, DEE Hussein - Journal of Genetic …, 2021 - Springer
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …

Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of …

FM Tette, SK Kwofie, MD Wilson - Current Issues in Molecular Biology, 2022 - mdpi.com
The role of the microbiota–gut–brain (MGB) axis in mood regulation and depression
treatment has gained attention in recent years, as evidenced by the growing number of …

[HTML][HTML] The involvement of descending pain inhibitory system in electroacupuncture-induced analgesia

Q Lv, F Wu, X Gan, X Yang, L Zhou, J Chen… - Frontiers in integrative …, 2019 - frontiersin.org
Chronic pain is a major health problem, which would impair life quality and reduce
productivity. Electroacupuncture (EA), a modality of medicine based on the theories of …

[HTML][HTML] Physiology, GABA

BE Jewett, S Sharma - 2018 - europepmc.org
Gamma-aminobutyric acid (GABA) is an amino acid that serves as the primary inhibitory
neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. It …

The effect of oral capsule of Ocimum basilicum leaf extract on sleep quality and insomnia severity in menopausal women: A randomized clinical trial

FZ Karimi, H Hosseini, SR Mazlom… - Phytotherapy …, 2023 - Wiley Online Library
One of the complications of menopause is sleep disorders, which affect women's health.
Ocimum basilicum contains compounds that may affect sleep. The aim of this study was to …

Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice

VT Pedrón, EM Canero, AP Varani, AJ Aon… - European Journal of …, 2024 - Elsevier
Previous studies from our laboratory have shown sex differences in the behavioral,
molecular, and neurochemical manifestations of morphine withdrawal and they were related …

Effects of Viola odorata syrup on sleep quality in menopausal women: a randomized, triple-blind, controlled trial

FZ Karimi, N Nazari, F Lotfi, SR Mazloom, M Yousefi… - Sleep and …, 2024 - Springer
Purpose The present study aimed to assess the effects of Viola odorata syrup on the sleep
quality of postmenopausal women. Methods This triple-blinded randomized clinical trial was …

Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art

R Barak, G Goshtasbi, R Fatehi… - … Biochemistry and Behavior, 2024 - Elsevier
Along the conventional pathways, Renin-angiotensin system (RAS) plays a key role in the
physiology of the CNS and pathogenesis of psychiatric diseases. RAS is a complex …

Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice

HM Arshad, FD Ahmad, AH Lodhi - Drug Design, Development …, 2022 - Taylor & Francis
Aim Depression is a chronic recurrent neuropsychiatric disorder associated with
inflammation. This study explored the pharmacological activities of Aerva javanica leaves …

Elucidating the binding mechanisms of GABA and Muscimol as an avenue to discover novel GABA-mimetic small molecules

AR Issahaku, A Wilhelm, M Schutte-Smith… - Journal of …, 2024 - Taylor & Francis
Gamma-aminobutyric acid (GABA) signaling is the principal inhibitory pathway in the central
nervous system. It is critical in neuronal cell proliferation and fate determination. Any …