There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

High-grade glioma is one of the most lethal human cancers characterized by extensive
tumor heterogeneity. In order to identify cellular and molecular mechanisms that drive tumor …

Controlling reactive oxygen species (ROS) at sustainable levels can drive multiple facets of
tumor biology, including within the cancer stem cell (CSC) population. Tight regulation of …

In recent years, the classification of adult-type diffuse gliomas has undergone a revolution,
wherein specific molecular features now represent defining diagnostic criteria of IDH-wild …

Single-cell RNA sequencing (scRNA-seq) is a revolutionary tool for studying the physiology
of normal and pathologically altered tissues. This approach provides information about …

Immunotherapy is a promising new therapeutic field that has demonstrated significant
benefits in many solid-tumor malignancies, such as metastatic melanoma and non-small cell …

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and
is a common feature of cancer, with different cancer types exhibiting distinct patterns of …

Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying
mechanism of tumorigenesis and malignant progression, and has been documented in a …