Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis …

Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the
blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology …

Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis.
We show here that emperipolesis is a dynamic process mediated actively by both lineages …

Thrombocytopenia is a common problem among sick neonates admitted to the neonatal
intensive care unit. Frequently, platelet transfusions are given to thrombocytopenic infants in …

Dengue virus (DENV) infection can cause either self-limited dengue fever or hemorrhagic
complications. Low platelet count is one of the manifestations of dengue fever …

Platelet transfusions are often a life-saving intervention, and the use of platelet transfusions
has been increasing. Donor-derived platelet availability can be challenging. Compounding …

Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate
and maintain lifelong blood cell production. This functionality is achieved through their ability …

Cell type-specific transcription factors regulate the repertoire of genes expressed in a cell
and thereby determine its phenotype. The differentiation of megakaryocytes, the platelet …

Neonatal thrombocytopenia is widespread in preterm and term neonates admitted to
neonatal intensive care units, with up to one-third of infants demonstrating platelet counts< …

Background Recent clinical studies have shown that transfusions of adult platelets increase
morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist …