At the time of its first clinical application 100 years ago, insulin was presented as the cure for
people with diabetes mellitus. That transpired to be an overstatement, yet insulin has proven …

Insulin remains indispensable in the treatment of diabetes, but its use is hampered by its
narrow therapeutic index. Although advances in peptide chemistry and recombinant DNA …

Background Long-term microvascular and neurologic complications cause major morbidity
and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined …

Background In short acting insulin analogues the dissociation of hexamers is facilitated,
achieving peak plasma concentrations about twice as high and within approximately half the …

The primary goal of treatment of Type I (insulin-dependent) diabetes mellitus, both at onset
and after several years duration, is maintenance of near-normoglycaemia [1] to prevent the …

Insulin lispro, an insulin analog recently developed particularly for mealtime therapy, has a
fast absorption rate and a short duration of action. We compared insulin lispro and regular …

The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …

Insulin lispro is a human insulin analog that dissociates more rapidly than human regular
insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in …

The difference in amino acid composition between beef and porcine insulins and human
insulin was long thought to be responsible for the immunogenicity of these animal insulins in …

After more than half a century of treating diabetics with animal insulins, recombinant DNA
technologies and advanced protein chemistry made human insulin preparations available in …