Immunotherapy: reshape the tumor immune microenvironment
B Lv, Y Wang, D Ma, W Cheng, J Liu, T Yong… - Frontiers in …, 2022 - frontiersin.org
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …
The interactions between these components, which are divided into anti-tumor and pro …
Targeting adenosine in cancer immunotherapy to enhance T-cell function
S Vigano, D Alatzoglou, M Irving… - Frontiers in …, 2019 - frontiersin.org
T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
Cardiovascular adenosine receptors: expression, actions and interactions
JP Headrick, KJ Ashton, RB Rose'Meyer… - Pharmacology & …, 2013 - Elsevier
Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …
Xanthine scaffold: scope and potential in drug development
Medicinal plants have been the basis for discovery of various important marketed drugs.
Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline …
Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline …
[HTML][HTML] The resurgence of A2B adenosine receptor signaling
CM Aherne, EM Kewley, HK Eltzschig - Biochimica et Biophysica Acta (BBA …, 2011 - Elsevier
Since its discovery as a low-affinity adenosine receptor (AR), the A2B receptor (A2BAR), has
proven enigmatic in its function. The previous discovery of the A2AAR, which shares many …
proven enigmatic in its function. The previous discovery of the A2AAR, which shares many …
Turnover of AU‐rich‐containing mRNAs during stress: a matter of survival
C von Roretz, SD Marco, R Mazroui… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Cells undergo various adaptive measures in response to stress. Among these are specific
changes in the posttranscriptional regulation of various genes. In particular, the turnover of …
changes in the posttranscriptional regulation of various genes. In particular, the turnover of …
The A2b adenosine receptor modulates glucose homeostasis and obesity
H Johnston-Cox, M Koupenova, D Yang, B Corkey… - PloS one, 2012 - journals.plos.org
Background High fat diet and its induced changes in glucose homeostasis, inflammation
and obesity continue to be an epidemic in developed countries. The A2b adenosine …
and obesity continue to be an epidemic in developed countries. The A2b adenosine …
Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression
Background We investigated the role of A2B-adenosine receptor in regulating
immunosuppressive metabolic stress in the tumor microenvironment. Novel A2B-adenosine …
immunosuppressive metabolic stress in the tumor microenvironment. Novel A2B-adenosine …
Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC
ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease
resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5 …
resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5 …
The adenosine A2B G protein-coupled receptor: Recent advances and therapeutic implications
The adenosine A 2B receptor (A 2B AR) is one of four adenosine receptor subtypes
belonging to the Class A family of G protein-coupled receptors (GPCRs). Until recently, the A …
belonging to the Class A family of G protein-coupled receptors (GPCRs). Until recently, the A …