Pathophysiology of systemic sclerosis: current understanding and new insights

M Cutolo, S Soldano, V Smith - Expert review of clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Correlation between microvascular damage and internal organ involvement in scleroderma: focus on lung damage and endothelial dysfunction

M D'Oria, I Gandin, P Riccardo, M Hughes, S Lepidi… - Diagnostics, 2022 - mdpi.com
Background. Systemic sclerosis (SSc) is an incurable connective tissue disease
characterized by decreased peripheral blood perfusion due to microvascular damage and …

Automated assessment of absolute nailfold capillary number on videocapillaroscopic images: proof of principle and validation in systemic sclerosis

M Cutolo, AC Trombetta, K Melsens, C Pizzorni… - …, 2018 - Wiley Online Library
Background Absolute nailfold capillary number should be a putative biomarker in selected
rheumatic diseases but could be time‐consuming and not highly repeatable. Objective To …

Monitoring the microcirculation in the diagnosis and follow‐up of systemic sclerosis patients: Focus on pulmonary and peripheral vascular manifestations

B Ruaro, MG Nallino, A Casabella, F Salton… - …, 2020 - Wiley Online Library
Systemic sclerosis (SSc) is a connective tissue disease, characterized by vascular damage
and progressive fibrosis, affecting the skin and internal organs. The vascular changes …

The role of nailfold capillaroscopy in the assessment of internal organ involvement in systemic sclerosis: a critical review

S Soulaidopoulos, E Triantafyllidou, A Garyfallos… - Autoimmunity …, 2017 - Elsevier
Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic
sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the …

Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic

V Bernardino, A Rodrigues, A Lladó… - Rheumatology …, 2020 - Springer
Raynaud's phenomenon (RP) is frequent in autoimmune connective tissue diseases
(AICTD) and its approach includes nailfold capillaroscopy (NFC), as it is a non-invasive …

Nailfold capillaroscopic changes in patients with idiopathic pulmonary arterial hypertension and systemic sclerosis-related pulmonary arterial hypertension

A Corrado, M Correale, N Mansueto, I Monaco… - Microvascular …, 2017 - Elsevier
Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of
the vascular changes in systemic sclerosis (SSc). Lung microvascular changes can play a …

Nailfold capillaroscopy: tips and challenges

Y El Miedany, S Ismail, M Wadie, M Hassan - Clinical Rheumatology, 2022 - Springer
Although nailfold capillaroscopy (NFC) appears to have a bright future in clinical practice,
the lack of familiarity with the technique and how to interpret its outcomes is major barriers …

The relationship between pulmonary damage and peripheral vascular manifestations in systemic sclerosis patients

B Ruaro, M Confalonieri, F Salton, B Wade… - Pharmaceuticals, 2021 - mdpi.com
Systemic sclerosis (SSc) is an autoimmune disease, characterized by the presence of
generalized vasculopathy and tissue fibrosis. Collagen vascular disorder in SSc is due to …

Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study

A Arvanitaki, G Giannakoulas, E Triantafyllidou… - Respiratory …, 2021 - Springer
Background Although pulmonary vascular bed has been the main subject of research for
many years in pulmonary hypertension (PH), interest has recently started to divert towards …