Geriatric traumatic brain injury: epidemiology, outcomes, knowledge gaps, and future directions

RC Gardner, K Dams-O'Connor… - Journal of …, 2018 - liebertpub.com
This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident
TBI sustained in older adulthood (“geriatric TBI”) rather than on the separate, but related …

Traumatic brain injury in older adults: epidemiology, outcomes, and future implications

HJ Thompson, WC McCormick… - Journal of the American …, 2006 - Wiley Online Library
Traumatic brain injury (TBI) is a significant problem in older adults. In persons aged 65 and
older, TBI is responsible for more than 80,000 emergency department visits each year; three …

[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …

Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity

RC Gardner, JF Burke, J Nettiksimmons, A Kaup… - JAMA …, 2014 - jamanetwork.com
Importance Epidemiologic evidence regarding the importance of traumatic brain injury (TBI)
as a risk factor for dementia is conflicting. Few previous studies have used patients with non …

Race and insurance status as risk factors for trauma mortality

AH Haider, DC Chang, DT Efron, ER Haut… - Archives of …, 2008 - jamanetwork.com
Objective To determine the effect of race and insurance status on trauma mortality. Methods
Review of patients (aged 18-64 years; Injury Severity Score≥ 9) included in the National …

The meningeal transcriptional response to traumatic brain injury and aging

AC Bolte, DA Shapiro, AB Dutta, WF Ma, KR Bruch… - Elife, 2023 - elifesciences.org
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …

Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

RM Ritzel, SJ Doran, EP Glaser, VE Meadows… - Neurobiology of …, 2019 - Elsevier
After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality
and worse functional outcomes compared with younger persons. As neuroinflammation is a …

Traumatic brain injury: Mechanisms, manifestations, and visual sequelae

SH Rauchman, A Zubair, B Jacob… - Frontiers in …, 2023 - frontiersin.org
Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial

AC Mosenthal, DH Livingston, RF Lavery… - Journal of Trauma …, 2004 - journals.lww.com
Objective: Elderly patients (aged 60 years and older) have been demonstrated to have an
increased mortality after isolated traumatic brain injury (TBI); however, the prognosis of …

Evaluation and management of geriatric trauma: an Eastern Association for the Surgery of Trauma practice management guideline

JF Calland, AM Ingraham, N Martin… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND Aging patients constitute an increasing proportion of patients treated at
trauma centers. Previous and existing guidelines addressing care of the injured elder have …