The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Duchenne muscular dystrophy (DMD) is a fatal X-linked degenerative muscle disease
caused by the absence of the microtubule-associated protein dystrophin, which results in a …

During the past several years, our laboratory has searched for the mechanisms that link
changes in membrane potential to regulation of gene expression in skeletal muscle, a work …

Skeletal muscle contraction is triggered by the excitation-contraction (EC) coupling
machinery residing at the triad, a membrane structure formed by the juxtaposition of T …

Junctophilins (JPs) anchor the endo/sarcoplasmic reticulum to the plasma membrane, thus
contributing to the assembly of junctional membrane complexes in striated muscles and …

Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disease, caused by
mutations in the gene encoding dystrophin. DMD is characterized in humans and in mdx …

Background Electrical activity regulates the expression of skeletal muscle genes by a
process known as “excitation-transcription”(ET) coupling. We have demonstrated that …

In skeletal muscle fiber, excitation-contraction coupling corresponds to the sequence of
events occurring from action potential firing to initiation of contraction by an increase in …

Efficient intracellular Ca2+ ([Ca2+] i) homeostasis in skeletal muscle requires intact triad
junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal …

Voltage‐gated calcium channels represent the sole mechanism converting electrical signals
of excitable cells into cellular functions such as contraction, secretion and gene regulation …