Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …

The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

Neutrophils are essential innate immune cells that extrude chromatin in the form of
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …

Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Plasmodium falciparum secretes extracellular vesicles (Pf EVs) that contain parasite-derived
RNA. However, the significance of the secreted RNA remains unexplored. Here, we …

Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with
severe malaria. Lactic acidosis causes physiological adverse effects, which can aggravate …

Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first
line of defense against invading foreign pathogens and might play a crucial role in malaria …

Background Appropriate treatment and management of children presenting with fever
depend on accurate and timely diagnosis, but current diagnostic tests lack sensitivity and …