Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial
cells and other cells in the joint can express and respond to cytokines and chemokines, and …

Neuroimmune diseases have diverse symptoms and etiologies but all involve pathological
inflammation that affects normal central nervous system signaling. Critically, many …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …

Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous
system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic …

Neuropathic pain can have a major effect on quality of life but current therapies are often
inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is …