Cancer may be defined as a progressive series of genetic events that occur in a single clone
of cells because of alterations in a limited number of specific genes: the oncogenes and …

Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as
integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to …

A 200–300 kb region of chromosome 3p14. 2, including the fragile site locus FRA3B, is
homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids …

Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases
(PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis …

Carcinogenesis is a multistage process driven by carcinogen-induced genetic and
epigenetic damage in susceptible cells that gain a selective growth advantage and undergo …

THE kinase activity of pp60 c-src is specifically and transiently increased during mitosis and
repressed during interphase1. Loss of cell-cycle control of pp60 c-src occurs on mutation of …

The protein tyrosine phosphatases (PTPs) are now recognized as critical regulators of signal
transduction under normal and pathophysiological conditions. In this analysis we have …

PURPOSE To review several recently described molecular abnormalities in lung cancer and
discuss their potential diagnostic and therapeutic relevance. DESIGN Articles were identified …

Publisher Summary This chapter discusses the methodological advantages and limitations
of the various approaches used to localize tumor suppressor genes on 3p, the short arm of …

Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation.
However, our ability to examine its biological function and role in disease is limited by the …