GABAA (γ-aminobutyric acid type A) receptors mediate most of the'fast'synaptic inhibition in
the mammalian brain and are targeted by many clinically important drugs. Certain naturally …

Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

Cenobamate is a novel antiepileptic drug under investigation for use in patients with focal
(partial-onset) seizures. To understand its potential molecular mechanism of action, the …

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain,
the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor …

Certain naturally occurring pregnane steroids act in a nongenomic manner to potently and
selectively enhance the interaction of the inhibitory neurotransmitter GABA with the GABAA …

Dentate granule cells are characterized by their low levels of excitability, an important aspect
of hippocampal function, which distinguishes them from other principal cells of the …

Abstract γ-Aminobutyric acid type A receptors (GABA A Rs) are the principal mediators of
fast synaptic inhibition in the brain as well as the low persistent extrasynaptic inhibition, both …

In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently
displays loss of neurons, including inhibitory interneurons. It is unclear whether surviving …

Purpose: Stiripentol (STP) is currently an efficient drug for add‐on therapy in infantile
epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent …

Benzodiazepines have been used for decades as first‐line treatment for status epilepticus
(SE). For reasons that are not fully understood, the efficacy of benzodiazepines decreases …