Cancer is still one of the most widespread diseases globally, it is considered a vital health
challenge worldwide and one of the main barriers to long life expectancy. Due to the …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Up to 40% of lung cancer patients develop brain metastasis, and the median survival of
these patients remains less than 6 months. Smoking is associated with lung cancer …

Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable
progress in lung cancer research made over the past decade, it is still the leading cause of …

Pharmacoresistance of cancer cells to many drugs used in chemotherapy remains a major
challenge for the treatment of cancer. Multidrug resistance transporters, especially ATP …

p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA
repair, apoptosis, and cell cycle arrest. More than 50% of human cancers have a mutated …

ABSTRACT Introduction Sesquiterpene lactones (SLs) are one of the most diverse bioactive
secondary metabolites found in plants and exhibit a broad range of therapeutic properties …

Liver cancer stem cells (LCSCs) are recognized as key contributors to
hepatocarcinogenesis, progression, and recurrence. Consequently, eradicating LCSCs has …

Parthenolide (PTL) is a sesquiterpene lactone derived from medicinal plant feverfew
(Tanacetum parthenium). Recent studies have demonstrated that it has multiple …

Objectives Chemotherapy is one of the major treatments of cancer. However, the emergence
of resistance to chemotherapeutic agents is still a major obstacle in the successful …