Alkaloids for cancer prevention and therapy: Current progress and future perspectives

A Mondal, A Gandhi, C Fimognari, AG Atanasov… - European journal of …, 2019 - Elsevier
Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

Emerging cytotoxic alkaloids in the battle against cancer: Overview of molecular mechanisms

Z Habli, G Toumieh, M Fatfat, ON Rahal… - Molecules, 2017 - mdpi.com
Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

Polyphenols: bioavailability, microbiome interactions and cellular effects on health in humans and animals

MB Scott, AK Styring, JSO McCullagh - Pathogens, 2022 - mdpi.com
Polyphenolic compounds have a variety of functions in plants including protecting them from
a range of abiotic and biotic stresses such as pathogenic infections, ionising radiation and …

Bisbenzylisoquinoline alkaloids

C Weber, T Opatz - The Alkaloids: Chemistry and Biology, 2019 - Elsevier
The present review covers the literature on bisbenzylisoquinoline alkaloids from 1999
through early 2018. About 500 natural products belong to this large alkaloid class, of which …

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

Y Jiang, M Liu, H Liu, S Liu - Phytochemistry Reviews, 2020 - Springer
Abstract Stephania tetrandra S. Moore (S. tetrandra) is distributed widely in tropical and
subtropical regions of Asia and Africa. The root of this plant is known in Chinese as “Fen …

Phytochemicals in anticancer drug development

R Dutt, V Garg, N Khatri… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
Background: In spite of major technological advances in conventional therapies, cancer
continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually …

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents

OR Johnson-Ajinwo, I Ullah, H Mbye… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract Thymoquinone (TQ), 2-isopropyl-5-methyl-1, 4-benzoquinone, a natural product
isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative …

Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells

IE Fadayomi, OR Johnson-Ajinwo, E Pires… - Molecules, 2021 - mdpi.com
Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics.
Drug discovery from edible and medicinal plants represents a promising approach towards …

[HTML][HTML] Vibrational spectra, molecular level solvent interaction, stabilization, donor-acceptor energies, thermodynamic, non-covalent interaction and electronic …

A Saral, A Manikandan, S Javed, S Muthu - Chemical Physics Impact, 2024 - Elsevier
The present research is a theoretical examination of 6-methoxyisoquinoline implementing
Density Functional Theory quantum mechanical approach. Structural optimization was …

Medicinal potential of heterocyclic compounds from diverse natural sources for the management of cancer

M Singh, P Sharma, PK Singh… - Mini Reviews in …, 2020 - ingentaconnect.com
Natural products form a significant portion of medicinal agents that are currently used for the
management of cancer. All these natural products have unique structures along with diverse …