[HTML][HTML] Relationship between frailty and Alzheimer's disease biomarkers: a scoping review

L Wallace, O Theou, K Rockwood… - Alzheimer's & Dementia …, 2018 - Elsevier
Introduction Frailty and dementia appear to be closely linked, although mechanisms remain
unclear. The objective was to conduct a scoping review of the association between frailty …

The impact of HIV central nervous system persistence on pathogenesis

BJ Brew, SL Barnes - Aids, 2019 - journals.lww.com
The persistence of HIV in the central nervous system is somewhat controversial particularly
in the context of HIV viral suppression from combined antiretroviral therapy. Further, its …

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

KL Hawkins, L Zhang, DK Ng, KN Althoff, FJ Palella Jr… - Aids, 2018 - journals.lww.com
Objective: The relationships between frailty and body composition in older adults with HIV
infection are poorly understood. We sought to describe associations between frailty and …

Association of immunosuppression and viral load with subcortical brain volume in an international sample of people living with HIV

TM Nir, JP Fouche, J Ananworanich… - JAMA network …, 2021 - jamanetwork.com
Importance Despite more widely accessible combination antiretroviral therapy (cART), HIV-1
infection remains a global public health challenge. Even in treated patients with chronic HIV …

Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection

BI Mitchell, IE Yazel Eiser, KJ Kallianpur… - Journal of …, 2024 - Springer
Background HIV-associated neurocognitive disorders (HAND) is hypothesized to be a result
of myeloid cell-induced neuro-inflammation in the central nervous system that may be …

Depression is associated with hippocampal volume loss in adults with HIV

M Bronshteyn, FN Yang, KF Shattuck… - Human brain …, 2021 - Wiley Online Library
Depressive symptoms are more prevalent in persons with HIV (PWH) than HIV‐uninfected
individuals. In HIV‐uninfected individuals, depression has been associated with atrophy in …

The structural and functional correlates of frailty in persons with human immunodeficiency virus

JF Strain, S Cooley, C Kilgore, B Nelson… - Clinical Infectious …, 2022 - academic.oup.com
Abstract Background Persons with HIV (PWH) are at increased risk of frailty, a clinically
recognizable state of increased vulnerability resulting from aging-associated decline in …

Transcriptomic and metabolomic changes might predict frailty in SAMP8 mice

L Dacomo, P La Vitola, L Brunelli, L Messa… - Aging …, 2024 - Wiley Online Library
Frailty is a geriatric, multi‐dimensional syndrome that reflects multisystem physiological
change and is a transversal measure of reduced resilience to negative events. It is …

Volumetric and diffusion abnormalities in subcortical nuclei of older adults with cognitive frailty

M Wan, R Xia, H Lin, P Qiu, J He, Y Ye, J Tao… - Frontiers in Aging …, 2020 - frontiersin.org
Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty
and cognitive impairment among older adults without dementia. Previous studies have …

The aging brain with HIV infection: effects of alcoholism or hepatitis C comorbidity

NM Zahr - Frontiers in aging neuroscience, 2018 - frontiersin.org
As successfully treated individuals with Human Immunodeficiency Virus (HIV)-infected age,
cognitive and health challenges of normal aging ensue, burdened by HIV, treatment side …