The large conductance calcium-and voltage-activated K+ channel (KCa1. 1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of
the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ …

The physiological functions of the urinary bladder are to store and periodically expel urine.
These tasks are facilitated by the contraction and relaxation of the urinary bladder smooth …

Ion channels are essential for the regulation of neuronal functions. The significance of
plasma membrane, mitochondrial, endoplasmic reticulum and lysosomal ion channels in the …

Large conductance, Ca2+-activated K+ (BK) channels represent an important pathway for
the outward flux of K+ ions from the intracellular compartment in response to membrane …

The clinical success of mirabegron as the first β 3-adrenoceptor (AR) agonist for treatment of
the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and …

Urine differs greatly in ion and solute composition from plasma and contains harmful and
noxious substances that must be stored for hours and then eliminated when it is socially …

Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the
bladder wall and ultimately determines the two main attributes of the organ: urine storage …

Bladder overactivity (OAB) is a multifactorial bladder disorder that requires therapeutics
superior to the current pharmacological treatment with muscarinic antagonists. β 3 …

Aim To review evidence for novel drug targets that can manage overactive bladder (OAB)
symptoms. Methods A think tank considered evidence from the literature and their own …