Continuously increasing understanding of the molecular triggers responsible for the onset of
diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening …

Members of the CCAAT/enhancer‐binding protein (C/EBP) family of transcription factors are
pivotal regulators of liver functions such as nutrient metabolism and its control by hormones …

Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1α) were produced by use of the
Cre-loxP recombination system. HNF-1α-null mice are viable but sterile and exhibit a …

The liver-enriched transcription factor C/EBPα has been implicated in the regulation of
numerous liver-specific genes. It was previously reported that mice carrying a homozygous …

Mutations in the hepatocyte nuclear factor-1α (HNF-1α) have been linked to subtype 3 of
maturity-onset diabetes of the young (MODY3), which is characterized by a primary defect in …

Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding
hepatocyte nuclear factor 1α (HNF1α) were identified in 50% of hepatocellular adenomas …

The hepatic transcriptional regulation by glucocorticoids of the cytosolic form of
phosphoenolpyruvate carboxykinase (PEPCK-C) gene is coordinated by interactions of …

Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in
the transcription factor hepatocyte nuclear factor-1a (HNF-1α) located on chromosome 12q …

Mutations in the hepatocyte nuclear factor (HNF)-1α gene have been linked to subtype 3 of
maturity-onset diabetes of the young (MODY), a disease characterized by a primary defect in …

For many years, adipose tissue has been mainly considered as an inert reservoir for storing
triglycerides. Since the discovery that adipocytes may secrete a variety of bioactive …