Alzheimer's disease (AD) is considered the most prevalent neurodegenerative disease and
the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1 …

Farber disease (FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-
PME) are ultra-rare, autosomal-recessive, acid ceramidase (ACDase) deficiency disorders …

Lipids play a crucial role in the entry and egress of viruses, regardless of whether they are
naked or enveloped. Recent evidence shows that lipid involvement in viral infection goes …

Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves
ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human …

Sphingolipids are both structural molecules that are essential for cell architecture and
second messengers that are involved in numerous cell functions. Ceramide is the central …

A marked reorganization of internal membranes occurs in the cytoplasm of cells infected by
single stranded positive-sense RNA viruses. Most cell compartments change their asset to …

β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism
by removing β-galactosyl moieties from β-galactosylceramide and β-galactosylsphingosine …

Recent evidence suggests that lipids play a crucial role in viral infections beyond their
traditional functions of supplying envelope and energy, and creating protected niches for …

Of all head and neck cancers (HNC), oral squamous cell carcinoma (OSCC) makes up 95%
of cases. Snuff use and alcohol intake are linked to 90% of individuals with oral cancer. The …

Microtubules (MTs) are the principal target for drugs acting against mitosis. These
compounds, called microtubule targeting agents (MTAs), cause a mitotic arrest during G2/M …