[HTML][HTML] Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Y Xu, J Xiong, X Sun, H Gao - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer immunotherapy has significantly flourished and revolutionized the limited
conventional tumor therapies, on account of its good safety and long-term memory ability …

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

YR Na, M Stakenborg, SH Seok… - … reviews Gastroenterology & …, 2019 - nature.com
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

[HTML][HTML] Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy

W Li, F Wu, S Zhao, P Shi, S Wang, D Cui - Cytokine & Growth Factor …, 2022 - Elsevier
Tumor immunotherapy, such as PD-1/PD-L1 blockade, has shown promising clinical efficacy
in patients with various types of tumors. However, the response to PD-1/PD-L1 blockade in a …

Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer

J Zhou, X Li, X Wu, T Zhang, Q Zhu, X Wang… - Cancer immunology …, 2018 - AACR
The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression
and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as …

Cell‐to‐cell communication: microRNAs as hormones

R Bayraktar, K Van Roosbroeck… - Molecular oncology, 2017 - Wiley Online Library
Mammalian cells can release different types of extracellular vesicles (EVs), including
exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs …

Nanoparticles and innate immunity: new perspectives on host defence

D Boraschi, P Italiani, R Palomba, P Decuzzi… - Seminars in …, 2017 - Elsevier
The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …

[HTML][HTML] Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway

W Zhang, X Zheng, Y Yu, L Zheng, J Lan… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Tumor-derived exosomes play a pivotal role in regulating tumor progression by mediating
crosstalk between tumor cells and immune cells such as macrophages within the tumor …

[HTML][HTML] Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype

X Chen, J Zhou, X Li, X Wang, Y Lin, X Wang - Cancer letters, 2018 - Elsevier
Recently, cancer has been considered to be a complex system that includes the tumor
microenvironment (TME). Tumor-associated macrophages (TAMs) are the most common …

The phospholipid research center: current research in phospholipids and their use in drug delivery

S Drescher, P van Hoogevest - Pharmaceutics, 2020 - mdpi.com
This review summarizes the research on phospholipids and their use for drug delivery
related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that …

Progress on modulating tumor‐associated macrophages with biomaterials

M Sylvestre, CA Crane, SH Pun - Advanced Materials, 2020 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are a complex and heterogeneous population of
cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor …