Importance Normal thyroid gland function is critical for early neurocognitive development, as
well as for growth and development throughout childhood and adolescence. Thyroid …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is
infrequently recognized by primary providers in the setting of physiologic jaundice …

Cholestatic jaundice in early infancy is a complex diagnostic problem. Misdiagnosis of
cholestasis as physiologic jaundice delays the identification of severe liver diseases. In the …

Suppression of the hypothalamic-pituitary-adrenal (HPA) axis has been shown to occur
during cholestatic liver injury. Furthermore, we have demonstrated that in a model of …

PSIS constitutes an antenatal anatomical defect. Neonatal hypoglycemia, cholestasis,
and/or micropenis with or without growth deficit should raise the possibility of combined …

Congenital growth hormone deficiency (GHD) is a rare disease caused by disorders
affecting the morphogenesis and function of the pituitary gland. It is sometimes found in …

The Hypothalamic-Pituitary-Adrenal (HPA) axis has an important role in maintaining the
physiological homeostasis in relation to external and internal stimuli. The HPA axis …

Hypopituitarism is defined as a decreased release of hypophyseal hormones, which may be
caused by disease of the pituitary gland disease or hypothalamus. The clinical findings of …

The aetiology of several liver diseases in children is age specific and many of these
conditions have significant and potentially long-term clinical repercussions if not diagnosed …