The human brain is characterised by the most diverse morphological, metabolic and
functional structure among all body tissues. This is due to the existence of diverse neurons …

Background: Design of small molecules which are able to bind to the protein responsible for
a disease is the key step of the entire process of the new medicine discovery. Atomistic …

The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung
cancer. Several lines of evidence show that lung cancer cells express all of the proteins …

Introduction: Docking and structure-based virtual screening (VS) have been standard
approaches in structure-based design for over two decades. However, our understanding of …

Introduction Several pharmacoepidemiological studies indicate that proton pump inhibitors
(PPIs) significantly increase the risk of dementia. Yet, the underlying mechanism is not …

Various pharmacoepidemiological investigational studies have indicated that Proton Pump
Inhibitors (PPIs) may increase the likelihood of developing Alzheimer's disease (AD) and …

The use of computer-aided drug design (CADD) for the identification of lead compounds in
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …

Photocatalytic H2 generation via water splitting is increasingly gaining attention as a viable
alternative for improving the performance of H2 production for solar energy conversion …

The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …

Microorganisms and plants can be important sources of many compounds with potential
pharmaceutical applications. Extraction of these matrices is one of the ways of identifying the …