Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

ML Merchant, IM Rood, JKJ Deegens… - Nature Reviews …, 2017 - nature.com
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …

Urinary biomarkers in bladder cancer: A review of the current landscape and future directions

K Ng, A Stenzl, A Sharma, N Vasdev - Urologic Oncology: Seminars and …, 2021 - Elsevier
Aim This narrative review aims to describe established and emerging urinary biomarkers in
the diagnosis and surveillance of non-muscle invasive bladder cancer. It provides a …

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

U Erdbrügger, CJ Blijdorp, IV Bijnsdorp… - Journal of …, 2021 - Wiley Online Library
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of
extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last …

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

AH Emwas, C Luchinat, P Turano, L Tenori, R Roy… - Metabolomics, 2015 - Springer
The metabolic composition of human biofluids can provide important diagnostic and
prognostic information. Among the biofluids most commonly analyzed in metabolomic …

Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers

R Liu, X Wang, K Aihara, L Chen - Medicinal research reviews, 2014 - Wiley Online Library
Many studies have been carried out for early diagnosis of complex diseases by finding
accurate and robust biomarkers specific to respective diseases. In particular, recent rapid …

Quantitative analysis of the intra-and inter-individual variability of the normal urinary proteome

N Nagaraj, M Mann - Journal of proteome research, 2011 - ACS Publications
Urine is a readily and noninvasively obtainable body fluid. Mass spectrometry (MS)-based
proteomics has shown that urine contains thousands of proteins. Urine is a potential source …

[HTML][HTML] The use of noninvasive and minimally invasive methods in endocrinology for threatened mammalian species conservation

DC Kersey, M Dehnhard - General and comparative endocrinology, 2014 - Elsevier
Endocrinology is an indispensable tool in threatened species research. The study of
endocrinology in threatened species not only advances knowledge of endocrine mechanism …

Biomarker discovery in mass spectrometry‐based urinary proteomics

S Thomas, L Hao, WA Ricke, L Li - PROTEOMICS–Clinical …, 2016 - Wiley Online Library
Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …

Protein glycosylation in urine as a biomarker of diseases

M Xu, A Yang, J Xia, J Jiang, CF Liu, Z Ye, J Ma… - Translational …, 2023 - Elsevier
Human body fluids have become an indispensable resource for clinical research, diagnosis
and prognosis. Urine is widely used to discover disease-specific glycoprotein biomarkers …

Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

A Khoo, M Govindarajan, Z Qiu, LY Liu… - Nature …, 2024 - nature.com
Urine is a complex biofluid that reflects both overall physiologic state and the state of the
genitourinary tissues through which it passes. It contains both secreted proteins and proteins …