The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and
CuIII oxidation states allowing it to act through one-electron or two-electron processes. As a …

Copper is an essential trace element in living systems, present in the parts per million
concentration range. It is a key cofactor in a diverse array of biological oxidation-reduction …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

The field of bioinorganic chemistry is at a propitious stage of development. Ever more
complex metallobiomolecules are isolated and purified, physical methodologies and …

Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705−762 | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

Electrophile responsive element (EpRE)-mediated gene induction is a pivotal mechanism of
cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS) …

The copper metalloenzyme, galactose oxidase [EC 1.1. 3.9](GO), 1-3 is an efficient oxidation-
reduction catalyst utilizing an unusual free radical-coupled copper catalytic motif1, 4, 5 in its …

Transcription factor Nrf2 regulates basal and inducible expression of phase 2 proteins that
protect animal cells against the toxic effects of electrophiles and oxidants. Under basal …

X-linked juvenile retinoschisis (XLRS, MIM 312700) is a common early onset macular
degeneration in males characterized by mild to severe loss in visual acuity, splitting of retinal …

The kelch motif was discovered as a sixfold tandem element in the sequence of the
Drosophila kelch ORF1 protein. The repeated kelch motifs predict a conserved tertiary …