Early intra-acinar events in pathogenesis of pancreatitis
Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …
of pancreatitis for more than a century. Recent development of novel models to study the …
Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer
Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …
Inflammation in acute and chronic pancreatitis
A Habtezion - Current opinion in gastroenterology, 2015 - journals.lww.com
Inflammation in acute and chronic pancreatitis : Current Opinion in Gastroenterology
Inflammation in acute and chronic pancreatitis : Current Opinion in Gastroenterology Log in or …
Inflammation in acute and chronic pancreatitis : Current Opinion in Gastroenterology Log in or …
[HTML][HTML] Immunopathogenesis of pancreatitis
T Watanabe, M Kudo, W Strober - Mucosal immunology, 2017 - Elsevier
The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due
to a genetic-or environment-based abnormality of intracellular acinar trypsinogen activation …
to a genetic-or environment-based abnormality of intracellular acinar trypsinogen activation …
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute
pancreatitis (AP) has not been clearly established. METHODS: We generated and …
pancreatitis (AP) has not been clearly established. METHODS: We generated and …
New insights into the pathogenesis of pancreatitis
Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …
NF-κB in acute pancreatitis: Mechanisms and therapeutic potential
A Jakkampudi, R Jangala, BR Reddy, S Mitnala… - Pancreatology, 2016 - Elsevier
The incidence of acute pancreatitis (AP) is increasing globally and mortality could be high
among patients with organ failure and infected necrosis. The predominant factors …
among patients with organ failure and infected necrosis. The predominant factors …
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
R Kang, Q Zhang, W Hou, Z Yan, R Chen, J Bonaroti… - Gastroenterology, 2014 - Elsevier
Background & Aims High mobility group box 1 (HMGB1) is an abundant protein that
regulates chromosome architecture and also functions as a damage-associated molecular …
regulates chromosome architecture and also functions as a damage-associated molecular …
The role of NF-κB activation in the pathogenesis of acute pancreatitis
Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form,
is associated with multi-organ failure and death. Recently, signalling molecules and …
is associated with multi-organ failure and death. Recently, signalling molecules and …
Role of oxidative stress in pancreatic inflammation
PS Leung, YC Chan - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen and reactive nitrogen species (ROS/RNS) have been implicated in the
pathogenesis of acute and chronic pancreatitis. Clinical and basic science studies have …
pathogenesis of acute and chronic pancreatitis. Clinical and basic science studies have …